Is a 5-Day Fast the Key to Longevity and Health? | Dr. Joseph Antoun 

The Longevity & Lifestyle podcast

The Longevity & Lifestyle podcast

The Longevity & Lifestyle podcast

Episode 131

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Performance coach, detail-loving educator, big-thinking entrepreneur, podcaster, mama, passionate adventurer, and health optimization activist here to help people transform their lives, and reach their highest potential! All rolled into one.

“If I can keep your metabolism and your cells younger than your age, I can keep you biologically younger from the inside. And therefore, you can have a higher chance of aging healthier and staying healthy longer.” - Dr. Joseph Antoun, Chairman and CEO of L-Nutra.

Is the secret to a healthy and long life a 5-day fast… With food?!

It sounds unbelievable, but it's true. You can fast with food, and this method is showing promising results in promoting longevity, fighting diseases such as type 2 diabetes, Alzheimer's, and cancer, and helping people healthily lose excess weight.

Here today to discuss this with me is the Chairman and CEO of L-Nutra, Dr. Joseph Antoun. Dr. Antoun is an expert in the field of nutritional practices for longevity, and he is currently researching and developing fasting-mimicking technology.

In this interview, we take a deeper look into his research findings, the ProLon nutrition program, Nutrition for Longevity, preventive care, and nutritional practices that promote longevity and healthy aging.

Tune in!




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Show Notes


Intro (00:00)
Eating and fasting for longevity (01:43)
ProLon: Fasting mimicking technology (07:41)
A good protocol for fasting (16:11)
Who shouldn’t do the ProLon program (26:24)
On longevity and the future of health (28:10)
Outro (34:21)


Intro (00:00)
Eating and fasting for longevity (02:21)
ProLon: Fasting mimicking technology (08:18)
A good protocol for fasting (16:48)
Who shouldn’t do the ProLon program (27:04)
On longevity and the future of health (28:50)
Outro (35:01)

People mentioned

  • xx


  • Metabolic Markers
  • Rejuvenate cells
  • Biological ageing
  • Fasting
  • Anabolic state during fasting
  • Growth Hormone
  • Insulin
  • IGF
  • Centenarians
  • Calorie Depletion
  • Autophagy


“The number one nutrition recommendation use is fasting daily for 12 to 14 hours. They don't snack late at night. Snacking at night is a big no-go. Because when you eat in the morning, you have the entire day to burn those calories. But when you eat late at night, you usually just go to sleep. It's not just that you're not burning the calories; at night, your body also goes into an anabolic state. Your body wants to rejuvenate, rest, and rebuild. So, your growth hormone is high, and your insulin spikes. And when you spike insulin, growth hormone, and IGF, while you have a lot of calories in the body, it all goes into fat and accelerated aging.” - Dr. Joseph Antoun, Chairman and CEO of L-Nutra

"Fasting is critical for people between the ages of 40 and 70. That's when fasting should be practiced so the body is not always forced into a growth and pre-disease state. Cancer is linked to eating a high-protein diet and eating frequently. Type 2 diabetes is a disease of overeating. We now even call Alzheimer's diabetes type 3. It is, therefore, crucial to slow down the impact of food on the body between the ages of 40 and 70. Because that only pushes you towards the onset of one of the chronic diseases, and these fasting periods will keep you away from them." - Dr. Joseph Antoun, Chairman and CEO of L-Nutra

“If I can keep your metabolism and your cells younger than your age, I can keep you biologically younger from the inside. And therefore, you can have a higher chance of aging healthier and staying healthy longer.” - Dr. Joseph Antoun, Chairman and CEO of L-Nutra

Legal Disclaimer: Please note, to avoid any unnecessary headaches, Longevity & Lifestyle LLC owns the copyright in and to all content in and transcripts of The Longevity & Lifestyle Podcast, with all rights reserved, as well as the right of publicity. You are welcome to share parts of the transcript (up to 500 words) in other media (such as press articles, blogs, social media accounts, etc.) for non-commercial use which must also include attribution to “The Longevity & Lifestyle Podcast” with a link back to the URL. It is prohibited to use any portion of the podcast content, names or images for any commercial purposes in digital or non-digital outlets to promote you or another’s products or services.


Claudia von Boeselager: Welcome to another episode of the Longevity and Lifestyle Podcast. I'm your host, Claudia von Boeselager. I'm here to uncover the groundbreaking strategies, tools, and practices from the world's pioneering experts to help you live your best and reach your fullest potential. Don't forget to subscribe to the podcast to always catch the latest episodes.

Legal Disclaimer: Please note, to avoid any unnecessary headaches, Longevity & Lifestyle LLC owns the copyright in and to all content in and transcripts of The Longevity & Lifestyle Podcast, with all rights reserved, as well as the right of publicity. You are welcome to share parts of the transcript (up to 500 words) in other media (such as press articles, blogs, social media accounts, etc.) for non-commercial use which must also include attribution to “The Longevity & Lifestyle Podcast” with a link back to the URL. It is prohibited to use any portion of the podcast content, names or images for any commercial purposes in digital or non-digital outlets to promote you or another’s products or services.


Dr. Joseph Antoun 0:00  
If I can keep your metabolism and your cells younger than your age, basically, I keep you biologically younger from the inside, and therefore, you can have a higher chance of having a better healthy aging and, therefore, staying healthier longer.

Claudia von Boeselager 0:15  
Are you ready to boost your longevity and unlock peak performance? Welcome to The Longevity and Lifestyle Podcast. I'm your host, Claudia von Boeselager, peak performance coach. Each week, we'll explore groundbreaking science, unravel longevity secrets, share strategies to grow younger, and stay up to date with world-class health and peak performance pioneers. Everything you need to live longer, live better, and reach your fullest potential ready to defy aging, optimize health, and promote peak performance. Visit for more.

My guest today is Dr. Joseph Antoon. Dr. Antoon has dedicated his professional experience to reforming health systems toward preventative care, which we know is so important. He is the CEO and chairman of L-Nutra, a company founded based on the science and research of Dr. Valter Longo and the Longevity Institute at the University of Southern California, USC. Dr. Antoon is passionate about bringing back fasting as a longevity practice to humanity. Dr. Antoon Joseph, what a pleasure to have you back on The Longevity and Lifestyle Podcast today.

Dr. Joseph Antoun 1:34  
Thank you, cloud. Yeah, and I think last time, we had a wonderful episode. Hopefully, people had a good chance to make a positive change in their lives, and we're gonna try to do the same today.

Claudia von Boeselager 1:43  
Exactly, exactly in front of people who are coming across you for the first time as well. I really would be excited to dig in because this is such an important space for people to live well. So, as an expert on longevity and fasting for living a long and healthy life, can you share what the latest nutrition for longevity discoveries are?

Dr. Joseph Antoun 2:05  
Yeah, for sure. You know, I work closely with longevity experts, particularly early when it comes to nutrition. I work very closely with Professor Valter Longo, and probably a lot of your audience today would, you know, have heard about his name. He's known today as ChatGPT, is the number one longevity nutrition in the world by ChatGPT, and the number one fasting expert in the world because he leads the only longevity nutrition program dietetic program at USC at the Longevity Institute of the University of Southern California. And I'm referring to him because he has the longevity diet book, which is an amazing read; I recommend everyone here to go and get it on Amazon or whatever your longevity diet book. And he's spent over two decades of his life looking at what humans should eat to live a healthy, long life. So a lot of what I'm going to talk about is going to be kind of the fruits and the results of the work he did to discover or uncover what we're going to talk about. So the approach that the Longevity Institute at USC took for nutrition is that first, they start studying centenarians, people living 100 and beyond, all the way from the blue zones around the world. We started going and seeing what they eat, how they live, and what their lifestyle is, and we wanted to learn and bring it back to our labs. In any lesson we get from their lifestyle, we bring it back. We tested in mice first. And then we go to human trials. Then, we try to prove the concept and human trust and whatever nutrition formulation prevails as helping us optimize the metabolic markers in the blood and or rejuvenate the cells. These under two very important, you know, healthy aging optimization is how can I reset my metabolism? And how can I rejuvenate myself? And when we do those together, we keep you biologically younger, right? And that's the goal of food for longevity. What is that concept? Everyone asked me how food could be a longevity promoter. It is actually okay if I can keep your metabolism and your cells younger than your age. Basically, I keep you biologically younger from the inside. And therefore, you can have a higher chance you cannot promise people to live long, but they have a higher chance of having better healthy aging and therefore staying, you know, healthier longer. Okay, so let's start with the recommendations. Yeah, I think the number one nutrition recommendation that centenarians apply actually, or they use, is actually this 12 to 14 hours of fasting, you know, they don't simplify that they don't snack late at night. It seems snacking at night is a big no-go. And we know that in science, why? Because when you eat in the morning, you have the entire day to burn. You're active; your mind is thinking when you go to work, or You're a mom, or you're busy, right? Your muscles are working; you burn it. And then when you eat late at night, you're going to sleep. It's not just that you're not burning the calories, but at night, you're, but it goes a little bit in what we call anabolic state. So, all these growth factors are high because the body wants to rejuvenate at night and rest and rebuild. But when you give a lot of calories, and the buddy thinks, Okay, I'm in a storage mode, I'm in anabolic mode. Growth hormone is high insulin spikes when you eat, and everything is going into storage. And when you spike insulin, you spike growth hormone and IGF while you have a lot of calories in the body that goes into fat and accelerated aging. So a lot of the centenarians eat their dinner from six to 8 pm. Some of them walk after that, some of them, you know, and there's other factors, none. None relate to nutrition, you know, they're, they're happy, they're living in their own net well listed at their own place. They stress less, they act, and they're active, but also, they don't snack late at night. And I think this is with us now. In the last decades, we've we've lost, right? We stay very late at night across Netflix and across flipping and our phones, the news, or Facebook, or Instagram or whatever that is, and or we're bringing a lot of work that we're late on and trying to work at night, so we're snacking a little bit, that extra snack seems to be very harmful. So a lot of people ask me, Should we do intermittent fasting by skipping breakfast, or why there's conflicting data on intermittent fasting is because people who skip breakfast eat late at night, and even the prac tried to practice intermittent fasting, but it's not working because eating late at night is actually worse than skipping food for 16 hours coming after. So the recommendation is to do your intermittent fasting and try to be 12 to 14 hours. You don't need to go 16 and 18 and 24 and all of that. And try just frontloaded. I always came up with this with FrontLoader. Intermittent fasting starts early in the evening. So that's that's the number one recommendation. Yeah, so

Claudia von Boeselager 7:02  
I think I mean, what are they a Dr. Satchin Panda on as well? And I think that the sort of rule of thumb that I'm hearing and let me know if you hear something else, but it's stop eating three to four hours before bed.

Dr. Joseph Antoun 7:13  
Yeah. Because then then also, when you're still active, you're still you're still a bit burning, and then you're still, and then you're sleeping. And then, when you sleep, you're sleeping on a body. That's a little bit anabolic, but it also starts to at the tail end of the night, you start, you know, inviting the body to start burning as well. Rather than always picking up fat and pushing biological aging throughout IGF and insulin.

Claudia von Boeselager 7:41  
Yeah. So, frontloading in the morning. And so we were saying about the nutrition and fasting, and some people are like, what doesn't make any sense? What are nutrition and fasting? How does it work? Yeah.

Dr. Joseph Antoun 7:54  
So, I'll transition from intermittent fasting to the second discovery for longevity. Is it a little bit of a longer fast? And so what we discovered, I mean, look, humanity never had enough food to eat all the time, right? We were eating some hours, and some days, there was no food. So, our buddy was living with fasting and feeding periods. There was never feeding, feeding, feeding, which is what we have today. And so we started studying. Almost now, 23 years ago, at different universities across the US and Europe. We started studying what happens to the body, and the body fasted for several days. And we discovered something really important, which is, you know, if you fast for a day or two, that's intermittent fasting, you lose weight, and you have a calorie depletion, which is great. A lot of people need that weight loss. It improves your blood pressure, your blood inflammation, and a lot of great markers. Now, when you cross the two fast, a special crisis happens to the body because the body is telling the cells I'm depleting my fat, right? I'm using fat as a reserve, and it's been two days. Now I cannot go any longer. You can get a fix on your operations, you can rejuvenate, and you're going to improve how you perform your job so that we survive as a whole. So, for the first time, we're seeing a stressful, positive signal to the cells telling the cells you've been spoiled with a lot of food, now you're gonna go back fix and rejuvenate. This phenomenon is called autophagy, or self-rejuvenation, and he won the Nobel Prize in Medicine in 2016. And that was a very big, you know, scientific kind of award to a phenomenal that we never knew before. This is not eating is as important to rejuvenate the body as eating and, ideally, you want to go for three to five days of fast if you go longer, you're just bankrupting the body. If you go shorter, you're you're losing weight, but you're not really. We need to get ourselves in, so five days of fasting turns out to be a really important period, but it's very difficult to fast and water. Again, if you stress the body, it's still stress. And so once we showed that fasting for five days was very important. We went to human trials to show what happens in humans. It was very difficult for people to fast for five days, and we weren't very happy. They weren't very happy and then said, so the National Institutes of Health helped us with actually a total of $20 billion. I think, historically now, to come up with what we call a fasting-mimicking nutrition or a fasting-mimicking diet. So basically, we put 18 universities together and research centers. And we took big, big dollars into the research, and we said, okay, how can we develop a plant base, gluten-free, lactose-free, very healthy, rich in healthy fats, low carbs, and plant-based sources of protein? How can we develop a precision nutrition formulation that you can eat for five days, but your body doesn't recognize the food? In order to do that, we started studying the cells, how they send food, and how the cell recognizes there's food or it's fasting. There are three receptors on the cell: the Tor pathway, the RAS pathway, and the pKa pathway. And these pathways, they tell their radars, we call them nutrient sensing pathways, they sense the food. And then we developed a diet that barely goes through the pathways without convincing the pathways that there's enough food. And it goes around the pathways with other molecules. So you're consuming food, you're not spiking systemically, insulin and IGF. And at the cellular level, the sensors of the cells are telling you, well, we're noticing a little bit of food. But we're not fully convinced to stay in a defensive mode and rejuvenate. And that's probably one of the biggest discoveries in nutrition, actually, in at least recent history. It has awarded till now over 50 patents. And you know, in food, getting a patent is almost impossible. That's with anywhere, and everything has been tried. So over 50 patents, including patents on preventing chronic conditions, do not claim their patents and patents on promoting longevity, which is the only product now in history to have a nutritional product that is fully patented and promotes human longevity in the US and in Europe, is the fasting-mimicking diet. So that there was a big, big discovery to kind of. And so we launched this product, it's called ProLon. We launched Pearl on the Five Days a few years ago. There's, I think, over a million now consumption of proline. And people use it to go through five days of mental reset, total body reset, there's a lot of metabolic markers that change, there's a lot of weight, actually fat and use weight loss. Fasting is the only intervention that protects muscles. It is very important because a lot of people now lose weight, either with chronic calorie restriction or the objectives Olympics or the others, and you lose muscle in all these types of, you know, weight classes. Fasting is a positive stress on the muscles. So, the rejuvenation of the muscle is critical. With prolonged fasting nutrition,

Claudia von Boeselager 13:18  
I just wanted to really highlight that point for people watching and listening, that, you know, the five-day fast and muscle degeneration. And this is really, really essential. And so it's really phenomenal that we're mimicking protocol that you've sold for a major issue with fasting for some people. And just to bear in mind that we're not talking about just like weightlifters and people who are, you know, building muscle. But, you know, think of also women it's very important to maintain muscle mass as we age as well. So this really applies to the whole spectrum of people.

Dr. Joseph Antoun 13:49  
It's critical, I think, for people between age 40 and 70. And women, especially when you're going through menopause, and Peri and post, but everyone who men and women between 840 and 70. This is where you need to definitely start practicing fasting to not always push your body towards growth and pre-disease, right? Cancer is also has been linked to the push of high protein diets and frequent eating. diabetes is definitely a disease of two most cases and type two, of overeating. Now, we're calling it Alzheimer's diabetes type three. So we know that between age 40 and 70, and actually we were about to publish a big article in nature, nature is the number one science. Don't have the word showing that if you do parole three times per year, between age 50 and 70, you're going to actually decrease your biological age by 11 years, which basically is closer to that four to five years of chronological age. So it's critical to slow down the food impact on the body between age 40 and 70. Because it's just pushing you towards starting one of the chronic diseases, and having these fasting periods kind of pull you back from

Claudia von Boeselager 14:59  
it. Yeah. I have a few questions about that as well. But Dr. Bredesen, the neurosciences, has been on as well. And he really pointed out that neurodegenerative diseases are 20 years in the making. So people think it's like, oh, when you're 70, or whatever, but actually, like from the age of 40, if you start really getting on top of all these different things, and doing this in the fasting periods, as you said, two or three times a year is the ideal protocol to see the results. Yeah,

Dr. Joseph Antoun 15:25  
this is where the drugs are failing and Alzheimer's, because it's already the damage the accumulation has happened. You gotta change your lifestyle early on, in to start in, in again, that 40 years is really an important and important, you know, Mark, and we believe that adopting intermittent fasting and or doing the prolonged five days, it's just a box that comes to your house, you buy it and ProLon on the website, And then you just you get to three times a year if you subscribe to three times, and you will rarely hear somebody think, you just do three days, just give me 15 days during that year, but they're powerful because the fasting impact on the cell and rejuvenate the cell is a very powerful intervention. Some people

Claudia von Boeselager 16:11  
might have been like, oh, I tried to fast once, and it didn't go so well. Is there a certain protocol you recommend in order to make sure that that transition goes as smoothly as possible?

Dr. Joseph Antoun 16:22  
Yeah, well, this is why we do fasting with nutrition because water fast, you know, is very effective, but it's also very difficult. Some people feel like the impact of water is more than the stress of it more than the benefits. So we have developed intermittent fasters. We have what we call a fast bar and fasting shake. They can replace one meal. So those who do intermittent fasting want to do the 12 hours, but they want to extend it to 16 hours instead of just being purely on the water for 16 hours. A lot of people are like, no, I want to just water fast for 16 hours. But please hear me here. Science shows that if you go long, especially when you skip breakfast in the morning, and you're just starving your body throughout the day, you lose weight, but you lose weight because the essential organs are asking for weight, right? So, for calories, the brain is thinking in the morning, the heart needs to pump, the muscles need to work, and the kidneys are filtering the blood. So don't starve your body when your buddies are prime during the day; feed it during the day and starve it overnight. This is where our science is trying to shape intermittent fasting by saying Don't skip breakfast and go all the way till two 3 pm. That's not the front-load intermittent fasting we talked about; just have your dinner early and do your breakfast. And if you don't want to make your breakfast, we have a fast bar, and we have a fasting shake that you can still take in the morning because we want to nourish your essential organs and mimic the fast, so a lot of people today do their 16 hours nourished fast but with the fasting shake and the fasting bar in the morning a lot of people to complete the portfolio so you have a one meal replacement and then a lot of people try to do the one day fast, you know, once or twice a week just to balance right and it comes from religion actually a lot of religions, you know, preach the Monday Wednesday or the Tuesday Thursdays right or the Fridays, you know with Christians do I think Tuesday for Virgin Mary and Friday for Good Friday. And so a lot of in Buddhism also have this a lot of divine religions, you know, had historically that once or twice a week fasting, which I think is important for the body as much as for prayers and the soul as well. In we have developed it for those who cannot do the full-day water fast. And again, we don't recommend that you always go on water fast. It's a stress with a product called reset, which is a one-day fasting nutrition. So you want to replace the meal you have the fast part and the fasting shake; you want to replace one day you have the reset. Again, it's a box that comes to your house; you open it and have the food that you can eat throughout the day, and your body stays in a fasting mode because that's what goes around the nutrient-sensing pathways. And if you want to do three times per year, you do ProLon three times a year

Claudia von Boeselager 19:11  
with the five days. Well, is there an optimal like what is research showing in terms of optimal is is it like good to do once a week, you know, the fasting day with the supporting with the nutrition that works really well. And then once a quarter, or I guess once every four months, right? The five-day fast? Is that a good cadence to get the optimal longevity benefits?

Dr. Joseph Antoun 19:32  
I would say it depends on people, right? I mean, if you're 40 and you're a woman, and you're, say, gaining weight a little bit fast, you're different than if you're 60. And you're so every age has a different in, but I'll say in general, if you're healthy in general, and you just want to rejuvenate the cells, you can do the prolonged three times per year if you're carrying more weight or you becoming pre-diabetic, and we just launched our diabetes program actually. So we were showing that we're at under percent better than current medication-inducing diabetes regression. 800% big number. And it's not a surprise that diabetes is a foodborne disease, right? I mean, it happens with overeating. And then suddenly fasting, which is a perception of non-eating, is, you know, I always get this big reaction from physicians or key opinion leaders. Wow, how come the fasting-mimicking diet is superior to getting medication? Of course, I mean, it's a disease of overeating, and then you send fasting signals to the body. It will reverse it the fastest, right? Amazing. And but because we went in medicine through the wrong way, and now we're uncovering what's obvious, and we're surprised by it. But yeah, then 100%. So when we launch a special program called Neutral Health for diabetes, that has diabetes, so the frequency then increases, so if you're, if you're getting a little bit of weight, you can do it up to four times per year. If you're pre-diabetic and touching diabetes, then you do it four to five times; if you're diabetic, what we tested as you do it six times, which is helping 67% of participants to reduce medication in six months,

Claudia von Boeselager 21:07  
which is beautiful. And I feel like everyone out there, if you know anybody who's diabetic or pre-diabetic, please let them know that it's possible to reverse it and not go down that path of diabetes, which is so cruel. Some end up in amputation, sometimes in blindness. I mean, it's such a painful disease. And you know, what Dr. Antony is sharing here, it's not necessary. It can be reversed by just a few days each year, right? So I love these amazing breakthroughs and news as well. So, I'm so excited for you to be sharing this here today. Can you talk to us about some other breakthrough stories that you've seen or use cases, if you will, from patients and clients who have been using the protocols we have

Dr. Joseph Antoun 21:47  
32 human trials now that are testing the fasting-mimicking nutrition for different purposes, longevity, weight, weight loss, and then pre-diabetes and then two on diabetes of eight on cancer, and we have one on Alzheimer's that we're testing into an autoimmune disease, Stanford University and University of Miami are doing the autoimmune diseases. And I don't want to be, you know, here selling the product for our for reversing a health condition because, you know, nutrition is not by regulatory is not position as a medicine although it is actually a very powerful medicine. What I will tell you is how we are conceptually testing the fasting-mimicking nutrition for health conditions. So, in, for example, in autoimmune conditions, you know, you have the body has the white cells, the immune cells are by mistake attacking one organ, right? It could be the thyroid we called Hashimoto. It could be skin was Cyrus's, psoriasis, etc., and fasting, actually, when you open, and I got the chance to see medical, medical either book back in like the last century, they had fasted in the old obeys. Fasting was part of the cure of autoimmune disease, I mean, cure, meaning remission, decreasing F layer net curing, meaning we're taking the entire disease off. But so, you know, the white blood cells, they when they attack an organ, they're replicating faster, they need calories to replicate, they're releasing cytokines and in that increases the temperature of the body. All this is calorie expenditure, heat calorie expenditure. So if you want to feel it to eat frequently, you feel that, and if you fast, what we're seeing is the body's actually cannot sustain growing white blood cells, and then it uses a high inflammatory state in the body because it spends calories. So it's, again, fasting works by stress, especially when you go over the second and third days. And so what we're seeing is the body trying to get rid of kills, actually, the T cells that are active and making the attack. And, you see the flare, the flare of the attack of the white blood cells on the organ decreases. And because it's also a rejuvenation, it's at the same time, we're seeing the damaged organ trying to heal out of out of that. So this is what we've seen in mice. We're testing that in humans right now again at Stanford and the University of Miami. It is so exciting. It's very promising, I think we're going to we're going to be very successful in autoimmune. The concept of fasting, again, has always been in traditional medicine to decrease the hyperexcitability of the immune system and attack and help the damaged organ rejuvenate. Cancer is actually something that we focus a lot on because, you know, once you have a cancer cell, it's a cell that lost the inhibition of non-replication. So it just keeps growing and doesn't matter if it's touching other cells that just keeps growing, and when it grows enough, it goes everywhere in the body and becomes metastatic, and it eats the entire, you know, energy and calorie intake of the body. So, unfortunately, traditionally, we say Oh, you have cancer. We're going to nourish your body because cancer is sucking the calories when you become frail. And then there's the side effects of chemo. And what he used to do the patients drinking high calorie, you know, boost and insurance and other stuff, too. But actually, you're nourishing cancer. cancer is the hungriest organ once you have it. And so we did the opposite. We started studying fasting before the chemotherapy. So when you fast, the cancer is lost and weakened because it lives on calories and suddenly cannot stop replicating. So it's, it's like somebody has to run a marathon and cannot stop, and then you stop in food and drink for that personal collapse in the same thing where cancer has to grow, cannot stop. And then you starve it. Starving cancer is very powerful. It gets lost. And so the strategy that we're testing, and we already published multiple times, and it is you fast with the fasting-mimicking nutrition to cancer, and then you hit it with chemo on day four or five or with immunotherapy or with tyrosine kinase or whatever therapy, depending on cancer, we've published twice on breast cancer, we're doing you know, common cancer now when and prostate cancer, etc. So we're seeing that the cancer is very much weakened when you fast before the chemotherapy hits it. We're seeing immune rejuvenation, so better immune attack, I guess cancer, so the entire body is rallying to get rid of cancer when the body goes into the positive stress of fasting.

Claudia von Boeselager 26:24  
It's so beautiful because it's just allowing the body to be at its best. And I think we forget that we're so brainwashed with marketing, and we need to be eating all the time and doing all these things. And actually, the body wants to repair. The body wants to be well. So by doing these fasts, you know, you're allowing that space in there to the body to rejuvenate, to heal to clear out the bad as well which, which is really, really phenomenal as well, so that they sound really, really promising. I'm excited to hear. Are there any use cases where you'd say, you know, this is not for people with this disease or over a certain age or under a certain Yeah,

Dr. Joseph Antoun 27:00  
the prolonged defy the fasting nutrition is, is you know, again, plant-based doesn't have any chemicals or or new chemical entity or biological, it's just just healthy, real healthy food. But it mimics fasting, so there are four profiles that probably should wait or should not do it first, if you have any allergies to the ingredients like food rights, and, and it's rich with pecan and macadamia actually, so if you have allergies to make a demand pecans, you should definitely not do it.

Claudia von Boeselager 27:29  
I find them delicious. And

Dr. Joseph Antoun 27:34  
then if you're pregnant, or you're lactating because you're growing another body within your body, and you have to produce milk. So you don't want to fast at that age. There is no reason to fast below the age of 18. You're not suffering from chronic, you know, from cancer or dementia or, or, or aging or above age 80 or 70 to 80. We recommend you see your doctor because what if you have chronic diseases and what if you're frail and your buddies can already? You don't want to fast that that persona, so allergies, you know, pregnancy, below age 80 and above age 7080 consult with your doctor if you want to do it

Claudia von Boeselager 28:10  
just to reconfirm, you could live to 150 years old, or I should rephrase that when you live 250 years old. How would you spend your time? I asked all my guests,

Dr. Joseph Antoun 28:24  
I've dedicated my life to medicine and longevity, I think I think time for me is positive memories. And as long as you're healthy, you can give back, and you have a purpose in life, I think it drives happiness. And we see this. We see this in the centenarians, right? What drives them to 200 Plus is mainly that happiness. And it's it's, you know, there are five factors that help our listeners here, five longevity if you want pillars, right? You have nutrition, and we talked a bit about nutrition. We have exercise, we have stress, we have sleep, and we have social capital and happiness. The two number one and two, compete is nutrition and happiness, and maybe that purposeful social capital wellness that happy is better because it drives everything right when you're happy and you and your content and you're feeling like you have great purpose in life and you by your family, etc. Then you eat healthier exe, raise more stress less, and sleep better. So it's like the mother of the other pillars. And I feel that you know, giving back to humanity and helping people live a better life is what drove me to start med school. And now, trying to bring back the science of longevity and health, helping people stay healthy longer. We don't want people to live long and sick. This is why we're watching our grandparents and our parents go through that, yes, and we don't want that. We want people to live healthy long and then die in a short in a short period so they don't suffer. My purpose is to try to ensure that in as many ways as possible.

Claudia von Boeselager 29:58  
Beautiful. What excites you most about the future of health, well-being, and longevity over the coming years and beyond?

Dr. Joseph Antoun 30:05  
What excites me the most is that there are a lot of concepts that we talked about today that were known even in the past but never implemented in health policy and health and public health and health care because the system of living was spoiled, right? There's a lot of money coming into healthcare. It's okay. Let's practice sick care. You know, we wait for people to be sick, and then everyone makes money when they're sick. And then and then, and then we die. And I think what excites me is, fortunately, but unfortunately, the system came to a crisis, and therefore, now, a lot of insurance and a lot of policymakers are looking for true solutions to decrease the bill. In health care. They're saying, Okay, it's time to do prevention, it's time to eat healthy, it's time to pay for food, you know, had to witness. One of our subsidiaries is called Nutrition for Longevity. And we sell meal kits, healthy meal kits at your units, your house. We call it nutrition for longevity. Last year, the government blessed us to be reimbursed in the US if we have one of 32 health conditions. Imagine how food is powerful 32 health care conditions. We ship you the food, you pay nothing if you're under Medicare or Medicaid, and now 93 insurances signed us. Wow. So what excites me is that that pressure on doing more prevention has led to paying for a healthy lifestyle. And we were able with our science to come in and show the government first, you know, thankful the NIH sponsors a lot of our trials, but now the payer's Medicare Medicaid and multiple insurance across the country Blue Cross Blue Shield, Aetna, United, you know, Humana, a lot of them, are paying for our food as medicine. This is probably one of the most exciting things because I went to med school, and I never learned anything about nutrition and it just throughout life. And throughout searching for true solutions. When I learned about the power of food, I always said it's the only product we put in our body every day, three to four times a day. It means to think about it, right? It's the day you're born to the day you die is one product you consume every day, right? They want us to inject the Olympics. They want us to take pills, which is one product you take by definition every day. Why have we not tailored that product to be on our site to help us live long hours, create happiness, and rejuvenate our bodies? We always just use it for pleasure and taste and for social gatherings. What excites me is that we were able to use hardcore science to switch that product into an enabler of longevity.

Claudia von Boeselager 32:40  
That's really, really a big breakthrough and exciting. And for people non-US based around the world, they might be like, Oh, what's the big deal if insurance pays for it? That's why so many people are dependent on their insurance companies actually paying for their support. And I was reading a study once. You know that the challenges of people with lower income, you know, when McDonald's or one of these other brands are offering $1 meals, they're obviously thinking, well budget constraints, I'm gonna go to McDonald's so to be able to get healthy longevity meals for free, covered by their carriers. This is a real game-changer. Hopefully, other countries around the world will follow suit as well. So that's really exciting

Dr. Joseph Antoun 33:16  
there. Well, we're working on it. Yes.

Claudia von Boeselager 33:21  
Where can people follow what you are up to on social media or websites? What would you like to share with people? Yeah,

Dr. Joseph Antoun 33:28  
I'm mostly active on LinkedIn and, in general, across all platforms at Dr. Joseph Anton's. My always is Dr. Just Fantastic is the same handle everywhere. If you want to read more about ProLon and fasting nutrition, you can go to And if you want to read about the company and what we stand for, our company is called L-Nutra. Is longevity through nutrition? It's right behind me. You can go to our website and read more about our mission and the story of our founder, Valter Longo, but if anything, today, I would like your listeners to buy the book, read the longevity diet, and be a game changer for your life. And then and then try ProLon, the five-day fasting nutrition three times a year. And if you're an intermittent faster, you want to replace your breakfast in the morning. You can do the fast part and the fasting shake. And this is how I'm able to touch your life positively with science on nutrition.

Claudia von Boeselager 34:21  
Yeah, it's really phenomenal. So thank you and also, Dr. Antoon. Your audience has kindly offered a 20% discount for the three times a-year subscriptions. If you use a checkout that codes CLAUDIA20, you can get 20% off, so thank you for offering that to my audience. Yeah, Lincoln. Sure. Um, do you have any final ask or recommendations or any parting thoughts or messages from my audience today?

Dr. Joseph Antoun 34:48  
I strongly advise that people you know have your family dinner a little bit earlier in the day and try again to do a little bit of exercise after that and then sleep probably that's one of the biggest In my humble experience, that's an I've seen a lot of interventions for longevity, being happy, sleeping on an A good, you know, fat overnight fasting and three times a year just rejuvenate in your bodies. I always use the analogy of a car race. And, you know, if you're racing, you're the pilot, and your engine is heated, and this is aging, right? You're going fast into an issue, one of the diseases you can slow down on the engine intermittent fasting, happiness exercise, right? And twice or three times during the race, you go into pitstop this prolong the mechanics come in, they put the system in check, and whatever is going wrong, they're going to fix it and send you back as the healthier car to stay longer in the race uniforms. So what I would recommend

Claudia von Boeselager 35:50  
to the pitstops and the beauty of it, actually, eat while doing it right so you're not just water and thinking the whole time, I can't actually do this. So I've done both. And I know it can be tricky with just water, so it's beautiful to have products like yours from fallen as well. Thank you so much for coming on the podcast today and very much for this as well. It's been beautiful. Thank you

I’m Claudia von Boeselager

Longevity Coach, detail-loving educator, big-thinking entrepreneur, podcaster, mama, passionate adventurer, and health optimization activist here to help people transform their lives, and reach their highest potential! All rolled into one.

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